THE EFFECT OF POLYMORPHIC GENES OF DETOXIFICATION SYSTEMS (CYP 1A1, CYP 1A2, CYP 2C9 (*2), CYP 2C9(*3), CYP 2C19, CYP 2E1(PSTI/RSAI), CYP 2E1(TAGI), CYP 3A4) ON THE THERAPEUTIC EFFICACY OF TREATMENT OF PATIENTS WITH LYMPHOPROLIFERATIVE DISEASES
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چکیده
منابع مشابه
Expression and Functional Analysis of CYP 2 D 6 . 24 , CYP 2 D 6 . 26 , CYP 2 D 6 . 27 and CYP 2 D 7
The objectives of this study were to compare the drug-metabolizing activity of human CYP2D6.24 (I297L), CYP2D6.26 (I369T), CYP2D6.27 (E410K) allelic isoforms with wild-type CYP2D6.1, and to express the CYP2D7 protein derived from an indel polymorphism (CYP2D7 138delT) and investigate its possible codeine O-demethylase activity. Successful creation of individual cDNAs corresponding to CYP2D6*24 ...
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BACKGROUND Genetic polymorphisms of metabolizing enzymes may affect the risk of cancer formation in humans. Since the diet can contain polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HAs), the relationship between polymorphisms of enzymes involved in PAH and HA metabolism and the occurrence of sporadic colorectal cancer was studied. PATIENTS AND METHODS Five hundred colorecta...
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PURPOSE There is a strong scientific rationale to support the view that cytochrome P450 (CYP P450) enzyme-inducing AEDs induce bone loss in patients with epilepsy. However, no study has investigated the association between CYP 2C9 polymorphism and bone mineral density (BMD), 25-hydroxyvitamin D or parathyroid hormone levels in patients with epilepsy. This study sought to determine the associati...
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In hepatic S9 and human liver microsomes (HLMs) the sulfoximine moiety of the ATR inhibitor AZD6738 is metabolized to its corresponding sulfoxide (AZ8982) and sulfone (AZ0002). The initial deimination to AZ8982 is nominally a reductive reaction, but in HLMs it required both NADPH and oxygen and also was inhibited by 1-aminobenzotriazole at a concentration of 1 mM. Studies conducted in a panel o...
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2000;67:603–6. 13. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–55. 14. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Ph...
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ژورنال
عنوان ژورنال: Современные проблемы науки и образования (Modern Problems of Science and Education)
سال: 2019
ISSN: 2070-7428
DOI: 10.17513/spno.29316